高功能化复合辅料的研究现况

冉飞, 张定堃, 慈志敏, 许润春, 韩丽

中国药学杂志 ›› 2020, Vol. 55 ›› Issue (10) : 794-798.

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中国药学杂志
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中国药学杂志 ›› 2020, Vol. 55 ›› Issue (10) : 794-798. DOI: 10.11669/cpj.2020.10.008
综述

高功能化复合辅料的研究现况

  • 冉飞, 张定堃, 慈志敏*, 许润春, 韩丽*
作者信息 +

Research Status of High Functional Co-processed Excipients

  • RAN Fei, ZHANG Ding-kun, CI Zhi-min*, XU Run-chun, HAN Li*
Author information +
文章历史 +

摘要

复合辅料通过对多种辅料结构与功能的重组,在流动性、紧实性、稀释性、压缩性等方面得以增强,成为优质药物制剂高质量高水平发展的重要基础,也是未来辅料工业发展的重要方向。笔者综述了复合辅料的发展历程、技术优势、影响因素、设计原则、制备方法,总结了复合辅料的工业化开发现状,以期为新时代复合辅料的研制开发提供参考。

Abstract

Co-processed excipients are enhanced in terms of fluidity, compactness, dilution, and compressibility by restructuring the structure and function of various excipients,which has become an important basis for the high quality and high level development of high quality pharmaceutical preparations, and also an important direction for the future development of excipient industry. This paper mainly summarizes the development history, technological advantages, influencing factors, design principles, preparation methods of co-processed excipients, and summarizes the current situation of industrial development of co-processed excipients, which provides a reference for the in-depth study of composite excipients.

关键词

复合辅料 / 技术优势 / 设计原则 / 制备方法 / 工业化开发

Key words

co-processed excipient / technological advantage / design principles / preparation method / industrial development

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导出引用
冉飞, 张定堃, 慈志敏, 许润春, 韩丽. 高功能化复合辅料的研究现况[J]. 中国药学杂志, 2020, 55(10): 794-798 https://doi.org/10.11669/cpj.2020.10.008
RAN Fei, ZHANG Ding-kun, CI Zhi-min, XU Run-chun, HAN Li. Research Status of High Functional Co-processed Excipients[J]. Chinese Pharmaceutical Journal, 2020, 55(10): 794-798 https://doi.org/10.11669/cpj.2020.10.008
中图分类号： R944   

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基金

国家自然科学基金面上项目资助(81773918);成都中医药大学中药学学科特色创新科研团队资助(CXTD2018006)
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